Desperate Mrs. Seonju English Sub Pi Seon Ju works as an interior designer in a small neighborhood. She is married to Jeon Nam Jin, who is an ambitious architect. Although Pi Seon Ju is devoted to her husband, her husband falls in love with Jin Sang A, who will become the successor of an architecture company. To further pursue his love and ambitions, Jeon Nam Jin demands a divorce from Pi Seon Ju. After their divorce, Pi Seon Ju decides to start her new life.

Meanwhile, architect Kim So U is married to Jin Sang A. Unlike Jin Sang A, he is satisfied with a stable situation rather than being fueled with ambition. Due to his wife’s affair with Jeon Nam Jin, Kim So U gets divorced. After meeting Pi Seon Ju, Kim So U experiences a turning point in his life.